Immunosuppression and BVD

Volker Moennig

Acute postnatal infection with BVD virus causes mild BVD disease but can lead to increased susceptibility to other bovine diseases, including respiratory and enteric ones. This can cause considerable economic damage.

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The role of Bulls in BVD Transmission

George Caldow

Bull fertility is critical for high levels of production in beef herds. Infection with BVD virus can reduce semen quality and production, leading to infertility and reduced productivity. of BVD eradication plans (including BVD vaccines) should be implemented in order to avoid the adverse effects of BVD disease on their fertility

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Mucosal disease: origins and outcome in cattle

Volker Moennig

Mucosal disease is fatal bovine disease which originates from persistently infected animals. It is associated with a cp BVD virus biotype which arises from the mutation of a ncp biotype. Cp biotypes can cause huge lesions, especially in the GI tract, leading to fatal disease in cattle.

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Atypical BVD Disease Cases

Jozef Laureyns

BVD type 1b virus, typically associated with mild bvd disease, has recently given rise to two cases of very severe bovine disease. Atypical clinical manifestations emphasise the importance of laboratory bvd testing to identify the presence of BVD virus on the farm.

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Clinical Signs of BVD

Juan Manuel Loste

BVD is the most common viral disease of cattle in Europe but, due to its different clinical manifestations, it is hard to identify. One of the best known manifestations is the fatal mucosal disease, often characterized by anorexia, erosions and diarrhoea. Reproductive dysfunctions are another common sign of BVD disease in cattle.

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Role of transient infection

Francesco Testa

Acute infection leads to leukopenia, increased susceptibility to other diseases, and greater associated morbidity/mortality. Although persistently infected (PI) animals are primarily responsible for the spread of BVD disease, acutely infected animals also play an important role. By infecting pregnant animals, transiently viraemic cows can lead to the generation of PI animals.

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Infection of the foetus with BVD virus: different phases

Axel Mauroy

Infection with BVD virus leads to different disease outcomes according to the phase of bovine gestation. Infection during the first month of gestation may result in embryonic mortality, whereas infection during the second to fourth month may lead to the generation of persistently infected, immunotolerant calves. Infection later in gestation may lead to abortion and to congenital abnormalities.

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Generation of animals persistently infected with BVD virus

John Fishwick

Infection with BVD virus can lead to transient infection which usually causes no or mild disease in cattle. Infection of the dam in the first trimester of gestation can lead to persistent infection of the foetus. Persistently infected (PI) animals shed vast quantities of virus throughout their lives.

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